ea0099p301 | Endocrine-Related Cancer | ECE2024
Schauer Marc Philipp
, Stabile Andrea
, Landwehr Laura-Sophie
, Altieri Barbara
, Fassnacht Martin
, Weber Justus
, Hudecek Michael
Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy that produces glucocorticoids in 60% of cases causing clinically relevant hypercortisolism. Since, we observed in another study, that shaping these immunosuppressive and life-threatining properties with corticosteroid inhibitors not only led to a glucocorticoid receptor-related downregulation of ROR1 but also to the upregulation of another promising membrane bound oncogenic antigen* (AG), we sought to...